Annual ambient UVB at wavelengths that induce Vitamin D synthesis is
associated with reduced oesophageal and gastric cancer risk: a nested
case-control study
O'Sullivan, F., van Geffen, J., van Weele, M. and Zgaga, L.: 2018,
Photochem Photobiol. 94, 797-806.
doi: 10.1111/php.12915
Abstract
Vitamin D has been shown to be beneficial at reducing the risk of cancer,
however studies examining oesophageal and gastric cancer have been scarce
and findings inconsistent. The UK Biobank cohort was used for this nested
case-control study (N=3,732). Primary, incident oesophageal and gastric
cancer cases diagnosed after recruitment were identified via linkage to
National Cancer Registries. Tropospheric emissions monitoring internet
service database was used to calculate ambient annual UVB dose (D-UVB).
Conditional logistic regression was used to investigate the relationship
between annual ambient D-UVB and risk of oesophageal and gastric cancer and
odds ratios (OR) are reported. In total, 373 oesophageal and 249 gastric
cancer cases and 3,110 age- and gender-matched controls were included in the
study. We found a strong inverse association between annual ambient UVB and
odds of developing oesophageal or gastric cancer: compared to the lowest
tertile, OR for the highest tertile was 0.64 (95%CI: 0.51-0.79) in adjusted
analysis. The association was strengthened when restricted to oesophageal
cancer (OR = 0.60; 95%CI: 0.45-0.80), and oesophageal adenocarcinoma cases
(OR = 0.48; 95%CI: 0.34-0.68). Similar results were found in unadjusted and
stratified analysis. In conclusion, ambient UVB radiation is inversely
associated with the development of oesophageal and gastric cancer, even in a
high latitude country.
Abstract
Introduction
Methods
Results
Discussion
Supporting information
Acknowledgments
References
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created: 5 March 2018
last modified: 7 June 2022